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Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。
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Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 673 | 现货 | |
5 mg | ¥ 1,650 | 现货 | |
10 mg | ¥ 2,490 | 现货 | |
25 mg | ¥ 4,190 | 现货 | |
50 mg | ¥ 5,990 | 现货 | |
100 mg | ¥ 8,290 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,630 | 现货 |
产品描述 | Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor,. |
体内活性 | Adenosine amine congener (ADAC) 在噪声暴露后的最初24小时内,以超过50 μg/kg的剂量最为有效,能提供最高21 dB的保护(8-28 kHz范围内平均)。药动学研究显示,ADAC在静脉注射后,血浆中的半衰期短(5分钟),未检测到降解产物。 |
动物实验 | Adenosine amine congener (ADAC)??(25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration[1]. |
别名 | ADAC |
分子量 | 576.6 |
分子式 | C28H32N8O6 |
CAS No. | 96760-69-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 31.25 mg/mL (54.20 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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