Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 673 | 现货 | ||
5 mg | ¥ 1,650 | 现货 | ||
10 mg | ¥ 2,490 | 现货 | ||
25 mg | ¥ 4,190 | 现货 | ||
50 mg | ¥ 5,990 | 现货 | ||
100 mg | ¥ 8,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,630 | 现货 |
产品描述 | Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor,. |
体内活性 | Adenosine amine congener (ADAC) was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products. |
动物实验 | Adenosine amine congener (ADAC)??(25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration[1]. |
别名 | ADAC |
分子量 | 576.6 |
分子式 | C28H32N8O6 |
CAS No. | 96760-69-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (54.20 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7343 mL | 8.6715 mL | 17.343 mL | 43.3576 mL |
5 mM | 0.3469 mL | 1.7343 mL | 3.4686 mL | 8.6715 mL | |
10 mM | 0.1734 mL | 0.8672 mL | 1.7343 mL | 4.3358 mL | |
20 mM | 0.0867 mL | 0.4336 mL | 0.8672 mL | 2.1679 mL | |
50 mM | 0.0347 mL | 0.1734 mL | 0.3469 mL | 0.8672 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Adenosine amine congener 96760-69-9 GPCR/G Protein Neuroscience Adenosine Receptor P1 receptor otoprotective loss hearing Inhibitor apoptotic injury systemic A1-adenosine Cochlear inhibit Ca2+ neuroprotective ADAC inhibitor